CATH Domain 2f6wA00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Tyrosine-protein phosphatase non-receptor type 1

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt P18031

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTN1_HUMAN

Homo sapiens

Tyrosine-protein phosphatase non-receptor type 1

PDB	2F6W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors Klopfenstein, S.R., Evdokimov, A.G., Colson, A.-O., Fairweather, N.T., Neuman, J.J., Maier, M.B., Gray, J.L., Gerwe, G.S., Stake, G.E., Howard, B.W., Farmer, J.A., Pokross, M.E., Downs, T.R., Kasibhatla, B., Peters, K.G. Bioorg.Med.Chem.Lett.