CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family Bifunctional TENA-E protein

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q9ASY9
3.5.99.2
Aminopyrimidine aminohydrolase.
based on mapping to UniProt Q9ASY9
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
-!- Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.

UniProtKB Entries (1)

Q9ASY9
TENAE_ARATH
Arabidopsis thaliana
Bifunctional TENA-E protein

PDB Structure

PDB 2F2G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of gene locus At3g16990 from Arabidopsis thaliana
Blommel, P.G., Smith, D.W., Bingman, C.A., Dyer, D.H., Rayment, I., Holden, H.M., Fox, B.G., Phillips Jr., G.N.
Proteins
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