CATH Classification
Domain Context
CATH Clusters
| Superfamily | Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A |
| Functional Family | Ubiquitin carboxyl-terminal hydrolase 7 |
Enzyme Information
| 3.4.19.12 |
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q93009
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
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UniProtKB Entries (1)
| Q93009 |
UBP7_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 7
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PDB Structure
| PDB | 2F1W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol.
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