CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Neuraminidase 3

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q9Y3R4
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q9Y3R4
NEUR2_HUMAN
Homo sapiens
Sialidase-2

PDB Structure

PDB 2F12
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor
Chavas, L.M.G., Kato, R., Mann, M.C., Thomson, R.J., Dyason, J.C., von Itzstein, M., Fusi, P., Tringali, C., Venerando, B., Tettamanti, G., Monti, E., Wakatsuki, S.
To be Published