CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.40 | SH3 Domains |
Domain Context
CATH Clusters
| Superfamily | SH3 Domains |
| Functional Family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
Enzyme Information
| 3.1.4.11 |
Phosphoinositide phospholipase C.
based on mapping to UniProt Q8CIH5
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
|
UniProtKB Entries (1)
| Q8CIH5 |
PLCG2_MOUSE
Mus musculus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
|
PDB Structure
| PDB | 2EQI |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the SH3 domain from Phospholipase C, gamma 2
To be Published
|