CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Werner syndrome ATP-dependent helicase homolog |
Enzyme Information
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt O09053
|
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt O09053
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
UniProtKB Entries (1)
| O09053 |
WRN_MOUSE
Mus musculus
Werner syndrome ATP-dependent helicase homolog
|
PDB Structure
| PDB | 2E6L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
probing the roles of active site residues in 3'-5' exonuclease of werner syndrome protein
TO BE PUBLISHED
|