CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.26 | Dihydroorotate Dehydrogenase A; chain A, domain 2 |
|
2.30.26.10 | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Dihydroorotate Dehydrogenase A, chain A, domain 2 |
| Functional Family | Dihydroorotate dehydrogenase (fumarate) |
Enzyme Information
| 1.3.98.1 |
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q4D3W2
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.
|
UniProtKB Entries (1)
| Q4D3W2 |
PYRD_TRYCC
Trypanosoma cruzi strain CL Brener
Dihydroorotate dehydrogenase (fumarate)
|
PDB Structure
| PDB | 2E6D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry
|
