CATH Domain 2e2iA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.40	Barwin-like endoglucanases
	2.40.40.20

Domain Context

CATH Clusters

Superfamily	2.40.40.20
Functional Family	DNA-directed RNA polymerase II subunit RPB1

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt P04050

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P20434

RPAB1_YEAST

Saccharomyces cerevisiae S288C

DNA-directed RNA polymerases I, II, and III subunit RPABC1

PDB Structure

PDB	2E2I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. Cell(Cambridge,Mass.)