CATH Domain 2e2bA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P00519

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00519

ABL1_HUMAN

Homo sapiens

Tyrosine-protein kinase ABL1

PDB Structure

PDB	2E2B
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives Horio, T., Hamasaki, T., Inoue, T., Wakayama, T., Itou, S., Naito, H., Asaki, T., Hayase, H., Niwa, T. Bioorg.Med.Chem.Lett.