CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.620 | HUPs |
Domain Context
CATH Clusters
| Superfamily | HUPs |
| Functional Family |
Enzyme Information
| 6.3.4.19 |
tRNA(Ile)-lysidine synthetase.
based on mapping to UniProt O67728
(tRNA(Ile2))-cytidine(34) + L-lysine + ATP = (tRNA(Ile2))-lysidine(34) + AMP + diphosphate + H(2)O.
-!- The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNA(Ile) at the oxo group in position 2 of cytidine(34). -!- This modification determines both codon and amino acid specificities of tRNA(Ile).
|
UniProtKB Entries (1)
| O67728 |
TILS_AQUAE
Aquifex aeolicus VF5
TRNA(Ile)-lysidine synthase
|
PDB Structure
| PDB | 2E21 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis of the initial binding of tRNA(Ile) lysidine synthetase TilS with ATP and L-lysine
To be Published
|
