CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.930 | BirA Bifunctional Protein; domain 2 | |
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
Superfamily | Bira Bifunctional Protein; Domain 2 |
Functional Family |
Enzyme Information
6.1.1.27 |
O-phosphoserine--tRNA ligase.
based on mapping to UniProt Q59054
ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L- seryl-tRNA(Cys).
-!- In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys). -!- The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism. -!- Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73. -!- Formerly EC 6.1.1.n2.
|
UniProtKB Entries (1)
Q59054 |
SEPS_METJA
Methanocaldococcus jannaschii DSM 2661
O-phosphoserine--tRNA(Cys) ligase
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PDB Structure
PDB | 2DU7 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea.
Nat.Struct.Mol.Biol.
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