CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.103
L-threonine 3-dehydrogenase.
based on mapping to UniProt Q5SKS4
L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.
-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.

UniProtKB Entries (1)

Q5SKS4
TDH_THET8
Thermus thermophilus HB8
L-threonine 3-dehydrogenase

PDB Structure

PDB 2DQ4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of threonine 3-dehydrogenase
Omi, R., Yao, T., Goto, M., Miyahara, I., Hirotsu, K.
To be Published
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