CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.287 | Helix Hairpins | |
1.10.287.10 | S15/NS1, RNA-binding |
Domain Context
CATH Clusters
Superfamily | S15/NS1, RNA-binding |
Functional Family | ataxin-3 isoform X1 |
Enzyme Information
3.4.19.12 |
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P54252
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.
|
UniProtKB Entries (1)
P54252 |
ATX3_HUMAN
Homo sapiens
Ataxin-3
|
PDB Structure
PDB | 2DOS |
External Links | |
Method | SOLUTION NMR |
Organism | Escherichia |
Primary Citation |
Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.
Febs Lett.
|