CATH Domain 2dmrA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.55	Dimethylsulfoxide Reductase; domain 3
	3.90.55.10	Dimethylsulfoxide Reductase, domain 3

Domain Context

CATH Clusters

Superfamily	Dimethylsulfoxide Reductase, domain 3
Functional Family

Enzyme Information

1.7.2.3

Trimethylamine-N-oxide reductase.

based on mapping to UniProt Q52675

Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+).

-!- Contains bis(molybdopterin guanine dinucleotide)molybdenum cofactor. -!- The reductant is a membrane-bound multiheme cytochrome c. -!- Also reduces dimethyl sulfoxide to dimethyl sulfide.

1.8.5.3

Respiratory dimethylsulfoxide reductase.

based on mapping to UniProt Q52675

Dimethylsulfide + menaquinone + H(2)O = dimethylsulfoxide + menaquinol.

-!- The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor. -!- It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron- sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool. -!- The electrons are passed through DmsB to DmsA and on to DMSO. -!- The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity.

UniProtKB Entries (1)

Q52675

DSTOR_RHOCA

Rhodobacter capsulatus

Dimethyl sulfoxide/trimethylamine N-oxide reductase

PDB Structure

PDB	2DMR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molybdenum Active Centre of Dmso Reductase from Rhodobacter Capsulatus: Crystal Structure of the Oxidised Enzyme at 1.82-A Resolution and the Dithionite-Reduced Enzyme at 2.8-A Resolution Mcalpine, A.S., Mcewan, A.G., Shaw, A., Bailey, S. J.Biol.Inorg.Chem.