CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Prostaglandin reductase 2 |
Enzyme Information
| 1.3.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q9EQZ5
|
| 1.3.1.74 |
2-alkenal reductase (NAD(P)(+)).
based on mapping to UniProt Q9EQZ5
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
-!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
|
| 1.3.1.48 |
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q9EQZ5
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).
|
UniProtKB Entries (1)
| Q9EQZ5 |
PTGR1_CAVPO
Cavia porcellus
Prostaglandin reductase 1
|
PDB Structure
| PDB | 2DM6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy
J.Biochem.(Tokyo)
|