CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.620 | HUPs |
Domain Context
CATH Clusters
| Superfamily | HUPs |
| Functional Family | tRNA-specific 2-thiouridylase MnmA |
Enzyme Information
| 2.8.1.13 |
tRNA-uridine 2-sulfurtransferase.
based on mapping to UniProt P25745
A [protein]-S-sulfanyl-L-cysteine + uridine(34) in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine(34) in tRNA + AMP + diphosphate + acceptor.
-!- The enzyme, found in bacteria, catalyzes formation of the 2-thiouridine modification in the wobble position of tRNA(Gln), tRNA(Lys) and tRNA(Glu).
|
UniProtKB Entries (1)
| P25745 |
MNMA_ECOLI
Escherichia coli K-12
TRNA-specific 2-thiouridylase MnmA
|
PDB Structure
| PDB | 2DEU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Snapshots of tRNA sulphuration via an adenylated intermediate
Nature
|