CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.30 | Elongation Factor Tu (Ef-tu); domain 3 | |
2.40.30.10 | Translation factors |
Domain Context
CATH Clusters
Superfamily | Translation factors |
Functional Family | tRNA-specific 2-thiouridylase MnmA |
Enzyme Information
2.8.1.13 |
tRNA-uridine 2-sulfurtransferase.
based on mapping to UniProt P25745
A [protein]-S-sulfanyl-L-cysteine + uridine(34) in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine(34) in tRNA + AMP + diphosphate + acceptor.
-!- The enzyme, found in bacteria, catalyzes formation of the 2-thiouridine modification in the wobble position of tRNA(Gln), tRNA(Lys) and tRNA(Glu).
|
UniProtKB Entries (1)
P25745 |
MNMA_ECOLI
Escherichia coli K-12
TRNA-specific 2-thiouridylase MnmA
|
PDB Structure
PDB | 2DEU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Snapshots of tRNA sulphuration via an adenylated intermediate
Nature
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