CATH Classification

Domain Context

CATH Clusters

Superfamily Calponin-like domain
Functional Family protein-methionine sulfoxide oxidase MICAL3 isoform X1

Enzyme Information

1.14.13.225
F-actin monooxygenase.
based on mapping to UniProt Q7RTP6
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.

UniProtKB Entries (1)

Q7RTP6
MICA3_HUMAN
Homo sapiens
[F-actin]-monooxygenase MICAL3

PDB Structure

PDB 2D88
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the CH domain from human MICAL-3 protein
Tomizawa, T., Kigawa, T., Koshiba, S., Inoue, M., Yokoyama, S.
To be Published