CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Quinate/shikimate dehydrogenase |
Enzyme Information
| 1.1.1.25 |
Shikimate dehydrogenase.
based on mapping to UniProt Q5SJF8
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
-!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
|
UniProtKB Entries (1)
| Q5SJF8 |
AROE_THET8
Thermus thermophilus HB8
Shikimate dehydrogenase (NADP(+))
|
PDB Structure
| PDB | 2D5C |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structures of Shikimate Dehydrogenase AroE from Thermus thermophilus HB8 and its Cofactor and Substrate Complexes: Insights into the Enzymatic Mechanism
J.Mol.Biol.
|
