CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.80 | Acyl-CoA Binding Protein |
|
1.20.80.10 |
Domain Context
CATH Clusters
| Superfamily | 1.20.80.10 |
| Functional Family | Enoyl-CoA delta isomerase 2, mitochondrial |
Enzyme Information
| 5.3.3.8 |
Delta(3)-Delta(2)-enoyl-CoA isomerase.
based on mapping to UniProt O75521
(1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
-!- The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. -!- Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system. -!- This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further. -!- The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. -!- The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
|
UniProtKB Entries (1)
| O75521 |
ECI2_HUMAN
Homo sapiens
Enoyl-CoA delta isomerase 2, mitochondrial
|
PDB Structure
| PDB | 2CQU |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution Structure of RSGI RUH-045, a Human Acyl-CoA Binding Protein
To be Published
|
