CATH Domain 2cnqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.470	D-amino Acid Aminotransferase; Chain A, domain 1
	3.30.470.20	ATP-grasp fold, B domain

Domain Context

CATH Clusters

Superfamily	ATP-grasp fold, B domain
Functional Family	Phosphoribosylaminoimidazole-succinocarboxamide synthase

Enzyme Information

6.3.2.6

Phosphoribosylaminoimidazolesuccinocarboxamide synthase.

based on mapping to UniProt P27616

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.

-!- Forms part of the purine biosynthesis pathway.

UniProtKB Entries (1)

P27616

PUR7_YEAST

Saccharomyces cerevisiae S288C

Phosphoribosylaminoimidazole-succinocarboxamide synthase

PDB Structure

PDB	2CNQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Saicar Synthase: Substrate Recognition, Conformational Flexibility and Catalysis. Urusova, D.V., Antonyuk, S.V., Grebenko, A.I., Levdikov, V.M., Barynin, V.V., Popov, A.N., Lamzin, V.S., Melik-Adamyan, W.R. To be Published