CATH Domain 2cflA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.40

Domain Context

CATH Clusters

Superfamily	3.10.450.40
Functional Family

Enzyme Information

1.4.3.21

Primary-amine oxidase.

based on mapping to UniProt P46881

RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881

PAOX_ARTGO

Arthrobacter globiformis

Phenylethylamine oxidase

PDB Structure

PDB	2CFL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter Globiformis. Langley, D.B., Brown, D.E., Cheruzel, L.E., Contakes, S.M., Duff, A.P., Hilmer, K.M., Dooley, D.M., Gray, H.B., Guss, J.M., Freeman, H.C. J.Am.Chem.Soc.