CATH Domain 2cfkA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.98	Beta-galactosidase; Chain A, domain 5
	2.70.98.20	Copper amine oxidase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Copper amine oxidase, catalytic domain
Functional Family	Amine oxidase

Enzyme Information

1.4.3.21

Primary-amine oxidase.

based on mapping to UniProt P46881

RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881

PAOX_ARTGO

Arthrobacter globiformis

Phenylethylamine oxidase

PDB Structure

PDB	2CFK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Enantiomer-specific binding of ruthenium(II) molecular wires by the amine oxidase of Arthrobacter globiformis. Langley, D.B., Brown, D.E., Cheruzel, L.E., Contakes, S.M., Duff, A.P., Hilmer, K.M., Dooley, D.M., Gray, H.B., Guss, J.M., Freeman, H.C. J. Am. Chem. Soc.