CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.180 | Quinone Oxidoreductase; Chain A, domain 1 |
|
3.90.180.10 | Medium-chain alcohol dehydrogenases, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Medium-chain alcohol dehydrogenases, catalytic domain |
| Functional Family | Glucose 1-dehydrogenase |
Enzyme Information
| 1.1.1.120 |
Galactose 1-dehydrogenase (NADP(+)).
based on mapping to UniProt O93715
D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH.
-!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.
|
| 1.1.1.48 |
D-galactose 1-dehydrogenase.
based on mapping to UniProt O93715
D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH.
-!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
|
| 1.1.1.359 |
Aldose 1-dehydrogenase (NAD(P)(+)).
based on mapping to UniProt O93715
An aldopyranose + NAD(P)(+) = an aldono-1,5-lactone + NAD(P)H.
-!- The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity toward aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD(+) and NADP(+) with similar catalytic efficiency. -!- It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
|
| 1.1.1.47 |
Glucose 1-dehydrogenase (NAD(P)(+)).
based on mapping to UniProt O93715
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
-!- This enzyme has similar activity with either NAD(+) or NADP(+). -!- Cf. EC 1.1.1.118 and EC 1.1.1.119.
|
UniProtKB Entries (1)
| O93715 |
GLCDH_SACSO
Saccharolobus solfataricus
Glucose 1-dehydrogenase
|
PDB Structure
| PDB | 2CDC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
J. Biol. Chem.
|
