CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.370 | Glycoside hydrolase/deacetylase |
Domain Context
CATH Clusters
| Superfamily | Glycoside hydrolase/deacetylase |
| Functional Family |
Enzyme Information
| 3.5.1.104 |
Peptidoglycan-N-acetylglucosamine deacetylase.
based on mapping to UniProt Q8DP63
Peptidoglycan-N-acetyl-D-glucosamine + H(2)O = peptidoglycan-D- glucosamine + acetate.
-!- Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis. -!- The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively.
|
UniProtKB Entries (1)
| Q8DP63 |
PGDA_STRR6
Streptococcus pneumoniae R6
Peptidoglycan-N-acetylglucosamine deacetylase
|
PDB Structure
| PDB | 2C1I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.
Proc. Natl. Acad. Sci. U.S.A.
|
