CATH Domain 2by4A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1000	HAD superfamily/HAD-like

Domain Context

CATH Clusters

Superfamily	HAD superfamily/HAD-like
Functional Family	Calcium-transporting ATPase 1

Enzyme Information

7.2.2.10

P-type Ca(2+) transporter.

based on mapping to UniProt P04191

ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).

-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.

UniProtKB Entries (1)

P04191

AT2A1_RABIT

Oryctolagus cuniculus

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB	2BY4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells Soehoel, H., Jensen, A.L., Moller, J.V., Nissen, P., Denmeade, S.R., Isaacs, J.T., Olsen, C.E., Christensen, S.B. Bioorg.Med.Chem.