CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.590 | Creatine Kinase; Chain A, domain 2 |
|
3.30.590.10 | Glutamine synthetase/guanido kinase, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
| Functional Family | Glutamine synthetase |
Enzyme Information
| 6.3.1.2 |
Glutamine synthetase.
based on mapping to UniProt P9WN39
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.
|
UniProtKB Entries (1)
| P9WN39 |
GLN1B_MYCTU
Mycobacterium tuberculosis H37Rv
Glutamine synthetase
|
PDB Structure
| PDB | 2BVC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights.
Proc.Natl.Acad.Sci.USA
|
