CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.1160 | Carbamate kinase |
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3.40.1160.10 | Acetylglutamate kinase-like |
Domain Context
CATH Clusters
Superfamily | Acetylglutamate kinase-like |
Functional Family | Uridylate kinase |
Enzyme Information
2.7.4.22 |
UMP kinase.
based on mapping to UniProt Q8U122
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.
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UniProtKB Entries (1)
Q8U122 |
PYRH_PYRFU
Pyrococcus furiosus DSM 3638
Uridylate kinase
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PDB Structure
PDB | 2BRX |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Crystal Structure of Pyrococcus Furiosus Ump Kinase Provides Insight Into Catalysis and Regulation in Microbial Pyrimidine Nucleotide Biosynthesis.
J.Mol.Biol.
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