CATH Domain 2bccE01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.270	Ubiquinol cytochrome reductase, transmembrane domain

Domain Context

CATH Clusters

Superfamily	Ubiquinol cytochrome reductase, transmembrane domain
Functional Family	Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8

Quinol--cytochrome-c reductase.

based on mapping to UniProt P13272

Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).

-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (2)

P18946	CYB_CHICK Gallus gallus Cytochrome b
P23004	QCR2_BOVIN Bos taurus Cytochrome b-c1 complex subunit 2, mitochondrial

PDB Structure

PDB	2BCC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Electron Transfer by Domain Movement in Cytochrome Bc1 Zhang, Z., Huang, L., Shulmeister, V.M., Chi, Y.I., Kim, K.K., Hung, L.W., Crofts, A.R., Berry, E.A., Kim, S.H. Nature