CATH Classification

Domain Context

CATH Clusters

Superfamily Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Functional Family

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P0C278
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0C278
FRDA_SHEFR
Shewanella frigidimarina
Fumarate reductase flavoprotein subunit

PDB Structure

PDB 2B7R
External Links
Method X-RAY DIFFRACTION
Organism Shewanella
Primary Citation
A Proton Delivery Pathway in the Soluble Fumarate Reductase from Shewanella frigidimarina.
Pankhurst, K.L., Mowat, C.G., Rothery, E.L., Hudson, J.M., Jones, A.K., Miles, C.S., Walkinshaw, M.D., Armstrong, F.A., Reid, G.A., Chapman, S.K.
J.Biol.Chem.