CATH Domain 2b76B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1060	Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
	1.10.1060.10	Alpha-helical ferredoxin

Domain Context

CATH Clusters

Superfamily	Alpha-helical ferredoxin
Functional Family	Succinate dehydrogenase iron-sulfur subunit

Enzyme Information

1.3.5.1

Succinate dehydrogenase (quinone).

based on mapping to UniProt P0AC47

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P0A8Q0

FRDC_ECOLI

Escherichia coli K-12

Fumarate reductase subunit C

PDB Structure

PDB	2B76
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Fumarate Reductase and Succinate Oxidase Activity of Escherichia coli Complex II Homologs Are Perturbed Differently by Mutation of the Flavin Binding Domain Maklashina, E., Iverson, T.M., Sher, Y., Kotlyar, V., Andrell, J., Mirza, O., Hudson, J.M., Armstrong, F.A., Rothery, R.A., Weiner, J.H., Cecchini, G. J.Biol.Chem.