CATH Domain 2b54A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941

CDK2_HUMAN

Homo sapiens

Cyclin-dependent kinase 2

PDB Structure

PDB	2B54
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases Markwalder, J.A., Arnone, M.R., Benfield, P.A., Boisclair, M., Burton, C.R., Chang, C.-C., Cox, S.S., Czerniak, P.M., Dean, C.L., Dolenaik, D., Grafstrom, R., Harrison, B.A., Kaltenbach III, R.F., Nugiel, D.A., Rossi, K.A., Sherk, S.R., Sisk, L.M., Stouten, P., Trainor, G.L., Worland, P., Seitz, S.P. J.Med.Chem.