CATH Domain 2azkA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

2.5.1.82

Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific).

based on mapping to UniProt Q97W92

Geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate.

-!- The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. -!- Formerly EC 2.5.1.33.

UniProtKB Entries (1)

Q97W92

HEXPP_SACS2

Saccharolobus solfataricus P2

Hexaprenyl pyrophosphate synthase

PDB Structure

PDB	2AZK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H., Wang, A.H.J. J.Bacteriol.