CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

2.5.1.82
Hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific).
based on mapping to UniProt Q97W92
Geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate.
-!- The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. -!- Formerly EC 2.5.1.33.

UniProtKB Entries (1)

Q97W92
HEXPP_SACS2
Saccharolobus solfataricus P2
Hexaprenyl pyrophosphate synthase

PDB Structure

PDB 2AZJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures
Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H., Wang, A.H.J.
J.Bacteriol.
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