CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.2350 | Pseudouridine synthase |
|
3.30.2350.10 | Pseudouridine synthase |
Domain Context
CATH Clusters
| Superfamily | Pseudouridine synthase |
| Functional Family | H/ACA ribonucleoprotein complex subunit CBF5 |
Enzyme Information
| 5.4.99.25 |
tRNA pseudouridine(55) synthase.
based on mapping to UniProt Q9V1A5
tRNA uridine(55) = tRNA pseudouridine(55).
-!- Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules. -!- The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54). -!- It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
|
UniProtKB Entries (1)
| Q9V0E3 |
NOP10_PYRAB
Pyrococcus abyssi GE5
Ribosome biogenesis protein Nop10
|
PDB Structure
| PDB | 2AUS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure determination and site-directed mutagenesis of the Pyrococcus abyssi aCBF5-aNOP10 complex reveal crucial roles of the C-terminal domains of both proteins in H/ACA sRNP activity
Nucleic Acids Res.
|
