CATH Domain 2anwA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Transmembrane protease serine

Enzyme Information

3.4.21.34

Plasma kallikrein.

based on mapping to UniProt P03952

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

-!- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. -!- Activates coagulation factors XII, VII and plasminogen. -!- Selective for Arg > Lys in P1, in small molecule substrates. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.21 and EC 3.4.21.8.

UniProtKB Entries (1)

P03952

KLKB1_HUMAN

Homo sapiens

Plasma kallikrein

PDB Structure

PDB	2ANW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J., Young, W., McGrath, M., Katz, B.A. J.Biol.Chem.