CATH Domain 2am1A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.20	Mur ligase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Mur ligase, C-terminal domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q8DNV6_STRR6

Streptococcus pneumoniae R6

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

PDB Structure

PDB	2AM1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure Longenecker, K.L., Stamper, G.F., Hajduk, P.J., Fry, E.H., Jakob, C.G., Harlan, J.E., Edalji, R., Bartley, D.M., Walter, K.A., Solomon, L.R., Holzman, T.F., Gu, Y.G., Lerner, C.G., Beutel, B.A., Stoll, V.S. Protein Sci.