CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q00944
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q00944
FAK1_CHICK
Gallus gallus
Focal adhesion kinase 1

PDB Structure

PDB 2AL6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the FERM Domain of Focal Adhesion Kinase
Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J.
J.Biol.Chem.