CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.30 | Roll | |
2.30.29 | PH-domain like | |
2.30.29.30 | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Domain Context
CATH Clusters
Superfamily | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Functional Family | focal adhesion kinase 1 isoform X1 |
Enzyme Information
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q00944
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
Q00944 |
FAK1_CHICK
Gallus gallus
Focal adhesion kinase 1
|
PDB Structure
PDB | 2AL6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem.
|