CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.80 | Alpha-Beta Horseshoe | |
3.80.20 | 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A | |
3.80.20.20 | Receptor L-domain |
Domain Context
CATH Clusters
Superfamily | Receptor L-domain |
Functional Family | Receptor protein-tyrosine kinase |
Enzyme Information
2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q15303
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
Q15303 |
ERBB4_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-4
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PDB Structure
PDB | 2AHX |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Cricetulus |
Primary Citation |
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA
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