CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.10 |
Domain Context
CATH Clusters
| Superfamily | 1.50.10.10 |
| Functional Family |
Enzyme Information
| 3.2.1.179 |
Gellan tetrasaccharide unsaturated glucuronosyl hydrolase.
based on mapping to UniProt Q9RC92
Beta-D-4-deoxy-Delta(4)-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap- (1->3)-D-Glcp + H(2)O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp- (1->4)-alpha-L-Rhap-(1->3)-D-Glcp.
-!- The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide beta-D-4-deoxy-Delta(4)-GlcAp-(1->4)-beta-D-Glcp- (1->4)-alpha-L-Rhap-(1->3)-D-Glcp produced by EC 4.2.2.25. -!- The enzyme can also hydrolyze unsaturated chondroitin and hyaluronate disaccharides (beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S, beta-D-4-deoxy- Delta(4)-GlcAp2S-(1->3)-beta-D-GalNAc, beta-D-4-deoxy-Delta(4)-GlcAp- (1->3)-beta-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides.
|
UniProtKB Entries (1)
| Q9RC92 |
UGL_BACGL
Bacillus sp. GL1
Unsaturated glucuronyl hydrolase
|
PDB Structure
| PDB | 2AHF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Unsaturated Glucuronyl Hydrolase Complexed with Substrate: MOLECULAR INSIGHTS INTO ITS CATALYTIC REACTION MECHANISM
J.Biol.Chem.
|
