CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Short-chain dehydrogenase reductase |
Enzyme Information
| 1.1.1.236 |
Tropinone reductase II.
based on mapping to UniProt P50163
Pseudotropine + NADP(+) = tropinone + NADPH.
-!- Represents, along with EC 1.1.1.206, a branch point in tropane alkaloid metabolism. -!- Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines. -!- Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific.
|
UniProtKB Entries (1)
| P50163 |
TRN2_DATST
Datura stramonium
Tropinone reductase 2
|
PDB Structure
| PDB | 2AE2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis.
Biochemistry
|
