CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1670 | Endonuclease Iii, domain 2 |
|
1.10.1670.10 | Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) |
Domain Context
CATH Clusters
| Superfamily | Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) |
| Functional Family | Endonuclease III |
Enzyme Information
| 4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt P0AB83
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
|
UniProtKB Entries (1)
| P0AB83 |
END3_ECOLI
Escherichia coli K-12
Endonuclease III
|
PDB Structure
| PDB | 2ABK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
EMBO J.
|
