CATH Domain 2abjJ02

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.10	D-amino Acid Aminotransferase; Chain A, domain 2
	3.20.10.10	D-amino Acid Aminotransferase, subunit A, domain 2

Superfamily	D-amino Acid Aminotransferase, subunit A, domain 2
Functional Family	Branched-chain-amino-acid aminotransferase

2.6.1.42

Branched-chain-amino-acid transaminase.

based on mapping to UniProt P54687

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

BCAT1_HUMAN

Homo sapiens

Branched-chain-amino-acid aminotransferase, cytosolic

PDB	2ABJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Hu, L.Y., Boxer, P.A., Kesten, S.R., Lei, H.J., Wustrow, D.J., Moreland, D.W., Zhang, L., Ahn, K., Ryder, T.R., Liu, X., Rubin, J.R., Fahnoe, K., Carroll, R.T., Dutta, S., Fahnoe, D.C., Probert, A.W., Roof, R.L., Rafferty, M.F., Kostlan, C.R., Scholten, J.D., Hood, M., Ren, X.D., Schielke, G.P., Su, T.Z., Taylor, C.P., Mistry, A., McConnell, P., Hasemann, C., Ohren, J. Bioorg.Med.Chem.Lett.