CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | U8 snoRNA-decapping enzyme |
Enzyme Information
| 3.6.1.62 |
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
based on mapping to UniProt Q6TEC1
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-diphosphate + 5'-phospho-[mRNA].
-!- Decapping of mRNA is a critical step in eukaryotic mRNA turnover. -!- The enzyme is unable to cleave a free cap structure (m(7)GpppG). -!- The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+). -!- Formerly EC 3.6.1.30.
|
| 3.6.1.64 |
Inosine diphosphate phosphatase.
based on mapping to UniProt Q6TEC1
(1) IDP + H(2)O = IMP + phosphate. (2) dIDP + H(2)O = dIMP + phosphate.
-!- The human enzyme also hydrolyzes GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
|
UniProtKB Entries (1)
| Q6TEC1 |
NUD16_XENLA
Xenopus laevis
U8 snoRNA-decapping enzyme
|
PDB Structure
| PDB | 2A8Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of U8 snoRNA decapping nudix hydrolase, X29, and its metal and cap complexes
Structure
|