CATH Domain 2a68C03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1110	Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
	3.90.1110.10	RNA polymerase Rpb2, domain 2

Domain Context

CATH Clusters

Superfamily	RNA polymerase Rpb2, domain 2
Functional Family

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt Q8RQE9

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SHR6

RPOA_THET8

Thermus thermophilus HB8

DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB	2A68
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G. Cell(Cambridge,Mass.)