CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.50 | Chitinase A; domain 3 |
|
3.10.50.10 |
Domain Context
CATH Clusters
| Superfamily | 3.10.50.10 |
| Functional Family | Endochitinase B1 |
Enzyme Information
| 3.2.1.14 |
Chitinase.
based on mapping to UniProt Q873X9
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.
|
UniProtKB Entries (1)
| Q873X9 |
CHIB1_ASPFM
Aspergillus fumigatus
Endochitinase B1
|
PDB Structure
| PDB | 2A3B |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol.
|
