CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | eukaryotic translation initiation factor 2-alpha kinase 3 |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P19525
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P19525
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (2)
P19525 |
E2AK2_HUMAN
Homo sapiens
Interferon-induced, double-stranded RNA-activated protein kinase
|
P20459 |
IF2A_YEAST
Saccharomyces cerevisiae S288C
Eukaryotic translation initiation factor 2 subunit alpha
|
PDB Structure
PDB | 2A1A |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.)
|