CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.260 | 434 Repressor (Amino-terminal Domain) |
|
1.10.260.40 | lambda repressor-like DNA-binding domains |
Domain Context
CATH Clusters
| Superfamily | lambda repressor-like DNA-binding domains |
| Functional Family | (S)-2-hydroxypropylphosphonic acid epoxidase |
Enzyme Information
| 1.11.1.23 |
(S)-2-hydroxypropylphosphonic acid epoxidase.
based on mapping to UniProt Q56185
(S)-2-hydroxypropylphosphonate + H(2)O(2) = (1R,2S)-1,2- epoxypropylphosphonate + 2 H(2)O.
-!- This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. -!- Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate. -!- Formerly EC 1.14.19.7.
|
UniProtKB Entries (1)
| Q56185 |
HPPE_STRWE
Streptomyces wedmorensis
(S)-2-hydroxypropylphosphonic acid epoxidase
|
PDB Structure
| PDB | 1ZZC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Nature
|
