CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.274 | Enzyme I; Chain A, domain 2 |
|
1.10.274.10 | PtsI, HPr-binding domain |
Domain Context
CATH Clusters
| Superfamily | PtsI, HPr-binding domain |
| Functional Family | Phosphoenolpyruvate-protein phosphotransferase |
Enzyme Information
| 2.7.3.9 |
Phosphoenolpyruvate--protein phosphotransferase.
based on mapping to UniProt P08839
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)- phospho-L-histidine.
-!- Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. -!- A similar reaction where the protein is the enzyme EC 2.7.9.2 is part of the mechanism of that enzyme.
|
UniProtKB Entries (1)
| P08839 |
PT1_ECOLI
Escherichia coli K-12
Phosphoenolpyruvate-protein phosphotransferase
|
PDB Structure
| PDB | 1ZYM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr.
Structure
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