CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.480
Functional Family rRNA adenine N(6)-methyltransferase

Enzyme Information

2.1.1.183
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase.
based on mapping to UniProt Q9UNQ2
4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)- dimethyladenine(1780) in 18S rRNA.
-!- DIM1 is involved in pre-rRNA processing. -!- Formerly EC 2.1.1.48.

UniProtKB Entries (1)

Q9UNQ2
DIM1_HUMAN
Homo sapiens
Probable dimethyladenosine transferase

PDB Structure

PDB 1ZQ9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human Dimethyladenosine transferase with SAM
Wu, H., Dong, A., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Plotnikov, A.
TO BE PUBLISHED